电喷雾离子阱质谱对具有强镇痛活性的新型双螺环哌嗪季铵盐的裂解方式研究

摘要

The fragmentation patterns of a series of dispirocyclopiperazinium dibromides with strong analgesic activity during positive ion electrospray ionization mass spectrometry were analyzed. The [M-Br]+ 2 ions showed the characteristic isotopic peaks and were assigned as the molecular ions. The loss of a 44 Dalton unit from 2 produced ion 3 [M-Br-44]+ and the loss of HBr from 2 formed ion 4. Besides, the carbamates 1d-le produced extra ions [M-2Br-33]+. The related fragmentation mechanisms were proposed.%我们研究了具有镇痛活性的螺环哌嗪季铵盐二溴代物1a-1e的一级和二级质谱.化合物1脱去溴负离子生成[M-Br]+峰2,离子2脱去溴化氢分子形成离子峰4,离子[M-Br-44]+3为基峰.化合物1d-1e由于是酰胺类化合物,除了上述几类峰外,还生成了离子碎片[M-2Br-33]+.