Objective The purpose was to explore the clinical effects and safety of gemcitabine plus nedaplatin in the treatment of advanced nasopharyngeal carcinoma.Methods From Mar 2013 to Aug 2014, we recruited 62 advanced nasopharyngeal carcinoma patients in our hospital. And the 62 cases were randomLy divided into control group(n=33) and treatment group(n=29). Patients in the control groups were treated with 5-fluorouracil 500 mg /m2+ 500 mL 0.9% sodium chloride injection intervenous drop infusion in day 1-5 plus cisplatin 20 mg /m2+500 mL 0.9% sodium chloride injection intervenous drop infusion in day 1-5 with 21 days per cycle for 3 cycles; And patients in the treatment group were given gemcitabine1000 mg/m2+500 mL 0.9% sodium chloride injection intervenous drop infusion in day 1 and 8 plus nedaplatin 20 mg /m2+500 mL 0.9% sodium chloride injection intervenous drop infusion in day 1 with 21 days per cycle for 3 cycles. The objective response rate and chemotherapy associated toxicities were compared between the two groups.Results After 3 cycle chemotherapy, the objective response rate were 39.39% and 79.31% in the control and treatment group respectively with statistical difference(P0.05).Conclusion The objective response rate was relative high for gemcitabine plus nedaplatin in the treatment of advanced nasopharyngeal carcinoma with main toxicity of haematological toxicity and gastrointestinal reaction.%目的：探讨吉西他滨联合奈达铂治疗晚期鼻咽癌的临床疗效及不良反应。方法入选2013年3月～2014年8月温州医科大学附属第六人民医院耳鼻喉科收治晚期鼻咽癌患者62例，并采用投硬币方法分为对照组33例和试验组29例。对照组给予5-氟尿嘧啶500 mg /m2＋500 mL 0.9%氯化钠注射液，静脉滴注，第1～5天；顺铂20 mg/m2＋500 mL 0.9%氯化钠溶液，静脉滴注第1～5天，21 d为1个周期，共化疗3个周期。试验组给予吉西他滨1000 mg/m2＋500 mL 0.9%氯化钠注射液，静脉滴注第1和8天；奈达铂20 mg/m2＋500 mL 0.9%氯化钠溶液，静脉滴注第1天，21 d为1个周期，共化疗3个周期。化疗结束后评价两组患者的客观缓解率及化疗不良反应。结果两组患者化疗3个周期后，对照组客观缓解率为39.39%，试验组为79.31%，试验组显著高于对照组，差异有统计学意义（P＜0.05）；两组患者主要化疗不良反应为血液学毒性和口腔黏膜溃疡，但两组Ⅲ～Ⅳ级不良反应发生率差异无统计学意义（P＞0.05）。结论吉西他滨联合奈达铂治疗晚期鼻咽癌客观缓解率较高，主要不良反为血液学毒性和胃肠道反应。
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