计算机认知矫正治疗对女性缓解期精神分裂症患者认知功能的影响

摘要

Objective To investigate the effect of computerized cognitive remediation therapy (CCRT) on cognitive function in female schizophrenia patients in remission. Methods This study included 42 female schizophrenia patients in remission who were treated at Shenyang Mental Health Center between September 2016 and September 2017. Patients were randomly divided into combined therapy and simple drug treatment groups. Patients in the combined therapy group were treated with oral olanzapine plus CCRT, which was used as cognitive therapy for 12 weeks. Those in the simple drug treatment group only received oral olanzapine for 12 weeks. The MATRICS consensus cognitive battery (MCCB) was used to evaluate cognitive function before treatment and 6 and 12 weeks after treatment. Results At12 weeks after treatment, significant differences were observed in symbol coding, digital sequence, spatial span, semantic fluency, continuous operation, speech memory, visual memory, maze, and total scores in the combined therapy group, while significant differences in symbol coding, semantic fluency, spatial span, speech memory, visual memory, and total scores were observed in the simple drug treatment group (all P ＜ 0.05). The MCCB scores in the combined therapy group were higher than those in the simple drug treatment group at 12 weeks after treatment, with statistically significant differences in continuous operation, digital sequence, speech memory, visual memory, maze, and total scores (P ＜ 0.05). Conclusion CCRT can significantly improve cognitive function in female schizophrenia patients in remission.%目的 探讨计算机认知矫正治疗 (CCRT) 对女性缓解期精神分裂症患者认知功能的影响.方法 收集2016年9月至2017年9月沈阳市精神卫生中心门诊治疗的42例女性缓解期精神分裂症患者, 随机分为联合治疗组和单纯药物治疗组, 联合治疗组在口服奥氮平的基础上同时采用CCRT作为认知治疗工具, 单纯药物治疗组仅口服奥氮平.试验共进行12周, 分别在治疗前、治疗6周后、治疗12周后应用精神分裂症认知功能成套测验共识版 (MCCB) 评定2组患者的认知功能.结果 与治疗前比较, 治疗12周后, 联合治疗组中符号编码、数字序列、空间广度、语义流畅、持续操作、言语记忆、视觉记忆、迷宫以及总分的差异有统计学意义 (P ＜0.05), 单纯药物治疗组中符号编码、语义流畅、空间广度、言语记忆、视觉记忆以及总分的差异有统计学意义 (P ＜0.05) .治疗12周后, 联合治疗组MCCB各项测验的分数均高于单纯药物治疗组, 其中持续操作、数字序列、言语记忆、视觉记忆、迷宫以及总分的差异有统计学意义 (P ＜0.05) .结论 CCRT对女性缓解期精神分裂症患者的部分认知功能有明显改善作用.