网织红细胞参数在贫血性疾病鉴别诊断中的应用

摘要

目的 探讨网织红细胞参数在各类贫血性疾病鉴别诊断中的临床应用.方法 采用Sysmex XE-2100血液分析仪检测各类贫血患者和健康体检者网织红细胞百分率(RET％)、网织红细胞绝对值(RET#)、未成熟网织红细胞比率(IRF)、低荧光强度网织红细胞百分率(LFR％)、中荧光强度网织红细胞百分率(MFR％)和高荧光强度网织红细胞百分率(HFR％).结果 溶血性贫血组RET％、RET#、IRF、MFR％、HFR％显著高于其他各类型的贫血(P＜0.01),而LFR％显著减低(P＜0.01).缺铁性贫血组、肾病性贫血组及肝病性贫血组与健康对照组比较,RET#的差异无统计学意义,而缺铁性贫血组MFR％、HFR％及IRF比健康对照组显著升高(P＜0.01),且升高的程度高于肾病性贫血组及肝病性贫血组.再生障碍性贫血组和白血病贫血组RET％、RET#低于其他各类型的贫血,白血病贫血组IRF较再生障碍性贫血组显著升高.结论 网织红细胞新型参数可以反映网织红细胞的成熟度,对不同类型贫血的鉴别诊断具有实用价值.%Objective To explore the clinical application value of reticulocyte parameters in anaemia differential diagnosis. Methods To analyze RET%,RET#,IRF,LFR%,MFR% and HFR% in the anaemia patients with different type and normal people with Sysmex XE-2100 automatic blood analyzer. Results RET%,RET#,IRF,MFR% and HFR% in patients with hemolytic anaemia were obviously higher than that of other groups and the LFR% was lower (P < 0.01) than that of other groups. Compared iron anaemia patients, renal anaemia patients and liver anaemia patients with health control, RET# was no significant differences among them, but MFR%, HFR% and 1RF were significantly increased in iron anaemia patients (P < 0.01). RET% and RET# in aplastia anaemia patients and leukemia anaemia patients were lower than that of other groups,and the IRF of leukemia anaemia patients was obviously higher than that of aplastia anaemia group. Conclusion Reticulocyte parameters could describe the mature of reticulocyte in detail, they had great clinical significance in anaemia differential diagnosis.