Microcytic Anemia With Iron Malabsorption: An Inherited Disorder of IronMetabolism

摘要

Two siblings were identified with severe hypoproilferative microcytic anemia andIron malabsorptlon, in the absence of any gastrointestinal disorder or blood loss. These children had severe microcytosis (MCV 48 ft, hemoglobin 7.5 g/di) with decreased serum iron, elevated serum TIBC, and decreased serum ferritin, despite prolonged treatment with oral iron. An iron challenge study with an oral dose of 2 mg/kg elemental iron as ferrous sulfate documented iron malabsorption. After treatment with intravenous iron dextran, there was an absence of the expected reticulocytosis and only a partial correction of tne hemoglobin, hematocrit, and microcytosis. The bone marrow was hypocellular with abnormal iron incorporation into erythrold precursor cells. This appears to be a rare form of inherited anemia characterized by iron malabsorption and disordered iron metabolism that only partially corrects after the administration of parenteral iron. These features resemble those found in the microcytic mouse (mk/mk), which also has severe microcytic anemia and iron malabsorotion that partially responds to parenteral iron.