超声心动图评价七氟醚诱导对新生儿及低龄婴儿左心功能的影响

摘要

Objective: To explore the significance of echocardiography in evaluating the effects of inhalational induction with different concentrations of sevofiurane on cardiac function of newborns and infants. Methods: Totally 24 infants from zero to three months old undergoing cutaneous hemangioma operation were randomly divided into three groups according to the inhalation concentration of sevoflurane(6%, 7%, 8%). The values of EF, SV, CO, HR, Sa, Ea and Tei index were calculated before and after induction. Results: After induction, the values of EF, SV, HR, Sa, Ea and Tei index were significantly different from the baseline values in each group(P<0.05). The values of EF, SV, CO, HR, Sa and Ea were not significantly different a-mong each group after induction(P>0.05), while the value of Tei index showed significant difference among the three groups(P< 0.05). The value of Tei index of infants inducted with 6% sevofiurane was lower than those of the groups of 7% and 8%(P< 0.05), while the latter two were similar(P>0.05). Conclusion: Cardiac function of newborns and infants is lower after inhalation induction with the three concentrations of sevofiurane. The influence of 6% sevofiurane is lower than that of 7% and 8%. Tei index can evaluate the effects of inhalational induction with sevofiurane on cardiac function of newborns and infants.%目的:对比不同浓度七氟醚诱导对新生儿及低龄婴儿左心功能的影响,探讨超声心动图在七氟醚对心功能影响的研究中的应用.方法:24名行皮肤血管瘤切除术患儿,分为6％、7％、8％三个七氟醚浓度组,分别于诱导前后测量射血分数(EF)、每搏量(SV)、心输出量(CO)、心率(HR)、二尖瓣环后间隔侧组织多普勒频谱Sa、Ea及Tei指数.结果:诱导后各组内Tei指数、SV与EF值增大,HR、Sa与Ea减小,差异有统计学意义(P＜0.05),CO差异无统计学意义(P＞0.05)；诱导后各组间EF值、SV、CO、HR、Sa与Ea差异无统计学意义(P＞0.05),6％组Tei指数小于7％、8％组,差异有统计学意义(P＜0.05),7％与8％组间差异无统计学意义(P＞0.05).结论:三种浓度七氟醚诱导均能造成新生儿及低龄婴儿左心室整体功能下降,6％浓度七氟醚诱导对左心功能影响最小,应用Tei指数可以敏感地反映出七氟醚对新生儿及低龄婴儿左心功能影响.