过敏性紫癜、湿疹、荨麻疹患者血清IgE对比分析

摘要

目的：：对比分析过敏性紫癜、湿疹、荨麻疹三种过敏性疾病患者血清中变应原特异性IgE和总IgE水平。方法：采用免疫印迹法检测341例过敏性疾病患者血清中总IgE和特异性IgE抗体水平。结果：过敏性紫癜、湿疹、荨麻疹患者总IgE阳性率分别为54.84%、65.79%、70.48%，以荨麻疹的阳性率最高。三种过敏性疾病吸入性变应原均以霉菌组合的阳性率最高；食入性变应原过敏性紫癜和湿疹牛奶的阳性率最高，荨麻疹以腰果类阳性率较高。结论：通过对三种过敏性疾病血清IgE的测定和对比分析，进一步证实Ⅰ型变态反应部分参与了过敏性紫癜和湿疹的致病；通过特异性变应原的测定，可了解引起患者过敏的变应原，为过敏性疾病的治疗和预防提供帮助。%Objective:To investigate the allergen-specific IgE and total IgE level in serum of patients with anaphylactoid purpura, eczema and urticaria.Methods: Immunoblotting was used to detect the allergen-speciifc IgE and total IgE level in serum of 341 cases allergic diseases patients.Results:The total IgE positive rate of anaphylactoid purpura, eczema and urticaria was respectively 54.84%, 65.79% and 70.48%; Among them, the positive rate of urticaria was the highest. For inhalant allergen, the positive rate of mold mixture was the highest in 3 allergic diseases. For food allergen, the positive rate of milk was the highest in anaphylactoid purpura and eczema; cashew allergies was the highest in urticaria. Conclusions:Comparative analysis of IgE level in serum of patients with 3 allergic diseases further conifrms that type I allergic reaction partly involves in allergic purpura and eczema. Determination of allergen can give a hand for treating and preventing allergic diseases.