Low-dose anti-lgE therapy in patients with atopic eczema with high serum IgE levels

摘要

To the Editor:In a preliminary experience with a limited patient number, we observed surprising success with low-dose anti-lgE therapy in selected adult patients with generalized atopic eczema and high levels of total IgE.' This therapeutic improvement was paralleled by a decrease in the mRNA ratio for IgE/IgG in the patients' PBMCs. We now have extended our analysis to a total group of 11 adult patients with severe generalized atopic eczema (3 of these patients have been reported previously)#