Compounds, pharmaceutical composition, and methods to simultaneously inhibit biological processes mediated by both leukotriene and histamine and to treat asthma, periodic and perennial allergic rhinitis, sinusitis, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media

摘要

"COMPOUND, PHARMACEUTICAL COMPOSITION, AND, METHODS FOR SIMULTANEOUSLY INHIBITING BIOLOGICAL PROCESSES AS MUCH BY LEUCOTRIEN AND BY HISTAMINE AND TO TREAT ASTHMA, PERIODIC ALLERGIC RHINITIS, EMERGENCY, SYNTHESIS, SYNTHESIS, SYNTHESIS, , RHEUMATOID ARTHRITIS, INFLAMMATORY INTESTINE DISEASE, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, THROMBOTIC DISEASE AND MIDDLE OTITIS ". The present invention provides 1,4-substituted piperazine compounds, 1,4-substituted piperidines, and 1-substituted 4-alkylidenyl piperidines. The compounds of the invention are dual-acting molecules having both leukotriene inhibiting properties as well as antihistaminic properties. The compounds of the invention are useful for treating conditions where there is likely to be a histamine and / or leukotriene component. These conditions preferably include asthma, periodic and perennial allergic rhinitis, sinusitis, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective amount that relieves asthma and rhinitis of the compounds to a patient in need thereof.