海洛因成瘾者停止吸毒后的脑功能变化

摘要

目的:探讨海洛因成瘾者在戒断期的脑功能的变化.方法:用功能磁共振检测15位海洛因成瘾者停止吸毒3d和1个月的静息状态下脑功能情况,并与16位正常对照者进行比较.结果:海洛因成瘾者在停止吸毒3d后功能磁共振成像显示其额叶出现血氧水平依赖（blood oxygen level dependent,BOLD）信号增加；而停止吸毒1个月后,BOLD信号的增加恢复正常.结论:海洛因成瘾者戒断后仍有脑功能的异常,其中部分异常可以随着戒断时间的延长而恢复.%Objective To explore what brain regions are modulated by heroin addiction and withdrawal.Methods We used functional magnetic resonance imaging to investigate the brain function in 15 heroin-dependent patients 3 days (acute) and 1 month (protracted) after heroin abstinence.Sixteen normal controls were included.Results The blood oxygen level-dependent signal in the orbitofrontal cortex of the brain of heroin-dependent patients was significantly elevated 3 days after the withdrawal.Hyperfunction of the orbitofrontal cortex declined 1 month after the withdrawal.Conclusion Heroin-dependent subjects at both 3 days and 1 month abstinence have persistent abnormalities in the brain function.Although some tangible beneficial effects are noted following 1month of detoxification,possible permanent damage to the brain caused by heroin use is suggested.