炎症因子促进结直肠癌发生发展

摘要

Objective To study the change of inflammatory factors at different stages of colorectal cancer (CRC). Methods Thirty normal subjects, 30 patients with colorectal adenomatous polyps and 120 CRC patients at different stages were enrolled. IgG, IgM, and lgA levels, the inflammatory cytokines IL-2, 4, 6, 10, and 12 and the expression of TGF-β1 and VEGF in the serum were analyzed by ELISA or immunoturbidimetry. Results The serum concentrations of IL-12, TGFβ1, and IL-6 in the CRC patients were statistically different compared with the normal and adenomatous polyps, and increased as the disease progressed ( P ＜ 0.05 ). IL-6 reached the highest level in C phase of CRC. The serum concentrations of IL-2, IL-4, and IL-10 were significantly different among the groups. VEGF serum levels in CRC Phase A and Phase B compared with other groups were statistically different, but other serum concentrations had no significant difference ( P ＞ 0.05 ).The serum level of IgG, IgM, and IgA in the 3 groups showed no significant difference (P ＞ 0.05 ).Conclusion The serum level of inflammatory cytokines TGF-β1, IL-6, and IL-12 increases gradually with the development of CRC, which may change the microcirculation of patients with CRC, and promote the development of CRC.%目的:研究不同阶段结直肠癌患者血清中与细胞免疫及体液免疫相关的炎症因子的改变.方法:对120例不同阶段结直肠癌患者、30例腺瘤性息肉患者和30例健康志愿者的血清通过ELISA检测IL-2,IL-4,IL-6,IL-10,IL-12,VEGF和TGF-β1血清浓度和免疫比浊法检测IgA,IgM,IgG血清浓度.结果:IL-12,IL-6和TGF-β1血清浓度随着结直肠癌发生发展逐渐升高(P<0.05),其中IL-6在结直肠癌C期最高.结直肠癌A期和B期的VEGF血清浓度升高,与其他各组比较差异有统计学意义(P<0.05).各组IL-2,IL-4和IL-10血清浓度差异无统计学意义(P>0.05).正常人、腺瘤息肉患者和结直肠癌患者血清中IgG,IgM,IgA的水平差异无统计学意义(P>0.05).结论:炎症因子TGF-β1,IL-6和IL-12血清浓度随结直肠癌发生发展而逐渐升高,可能通过改变结直肠癌患者微循环,促进结直肠癌发生发展.