替米沙坦对老年原发性高血压伴代谢综合征血尿酸和超敏C反应蛋白的影响

摘要

目的:探讨替米沙坦对老年原发性高血压伴代谢综合征患者,血尿酸和超敏C反应蛋白的影响.方法:将80例老年原发性高血压伴代谢综合征患者分为服用替米沙坦组和硝苯地平控释片组.每组40例,服药6个月,观察用药前、后血尿酸、超敏C反应蛋白、血糖及血脂等代谢指标.结果:替米沙坦组患者经6个月的治疗后的血尿酸及超敏C反应蛋白水平较用药前明显下降,差异有统计学意义(P＜0.05);而硝苯地平控释片组治疗后血尿酸及超敏C反应蛋白水平较用药前无明显变化(P＞0.05).结论:替米沙坦降低老年高血压伴代谢综合征患者的血尿酸及炎症因子水平.%Objective:To explore the effect of telmisartan on high sensitivity C-reactive protein ( hs-CRP) and serum unc acid in elder patients with hypertension and metabolic syndrome. Methods :40 patients with hypertension and metabolic syndrome orally received telmisartan and nifedipine for 6 months reapectively.The level of hs-CRP,serum uric acid, serum glucose,Blood Lipid were observed. Results : We observed an significant decrease of patients with orally received telmisartan in the level of serum uric acid and hs-CRP( P＜0.05) , But there was no change in patients with nifedipine( P ＞ 0. 05) . Conclusion : Telmisartan can decrease the level of serum uric acid and inflammatory factor in old patients with hypertension and metabolic syndrome.