目的:探讨早发冠心病患者非乙醇性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的患病率和危险因素.方法:冠状动脉造影诊断为早发冠心病的748例患者,入院期间进行空腹肝胆超声检查.结果:NAFLD患者发生率为49.6％(371/748).NAFLD组糖尿病,血清总胆固醇,三酰甘油,血清丙氨酸转氨酶及天冬氨酸转氨酶高于非NAFLD组,差异有统计学意义(P＜0.05).NAFLD组多支病变比率明显高于非NAFLF组(x2=4.455,P=0.04).多因素Logistic回归分析中,只有糖尿病和冠心病左主干病变是NAFLD的危险因素.结论:早发冠心病患者中NAFLD发生率高达50％,其中冠状动脉多支病变和糖尿病与NAFLD的发生密切相关.%Objective: The aim of this study was to investigate the incidence and risk factor of non-alcoholic fatty liver disease NAFLD in premature coronary artery disease in patients undergoing coronary angio-gram. Methods; 748 patients with premature coronary artery disease who underwent coronary angiogram were enrolled into this study. All patients had ultrasound screening for fatty liver. Results: Among 748 recruited patients, 341(49.6% )had fatty liver by ultrasonography. Incidence of NAFLD in the patients in multi - vessel disease was higher than those of 1-vessel disease^2 =4. 455 ,P = 0.04). By multivariable logistic regression a-nalysis, diabetes mellitus, stenosis of left main stem were risk factor in NAFLD·patients with premature coronary heart disease. Conclusion: Incidence of NAFLD was about 50% in premature coronary artery disease patients. The presence of NAFLD is associated with multi - vessel disease and diabetes mellitus.
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