Objective; To explore the curative effect and toxic reaction of Gemcitabine combined with intensity modulated radiation therapy(IMRT) for locally advanced pancreatic cancer. Methods; Thirty-six patients were treated by IMRT ( GTV D95 2Gy/f, total dose; 66Gy ~70Gy ) combined with Gemcitabine (1 000mg/m2 , intravenously, dl,d8, 28 days as one cycle, total 4 - 6 cycles) . Results; All patients finished the concurrent chemoradiotherapy. The total response rate was 88. 9% and the local control rate was 91. 6% . The medium survival time was 18. 6 months, and the 1-and 2-year survival rate was 60. 8% , 22. 1% respectivly. The pain-alleviation rate was 94% (34/36) . Life quality of patients improved obviously. ECOG score was improved in 19(52.8%) cases. Conclusion; Gemcitabine combined with IMRT is effective and well-tolerated for the treatment of locallyadvanced pancreatic cancinoma.%目的 探讨调强适形放疗(IMRT)联合吉西他滨同步治疗晚期胰腺癌的疗效及毒性.方法 36例接受IMRT联合吉西他滨同步放化疗治疗的晚期胰腺癌患者,放疗采用IMRT技术,GTV D95 2Gy/次,总量66Gy～70Gy.同步化疗方案为吉西他滨1 000mg/m2,d1,d8,四周重复与放疗同步,放疗结束后行同方案化疗,共4周期～6周期.结果 所有患者均完成同步放化疗.有效率为88.9%,局部控制率为91.6%,中位生存期为18.6个月,1年生存率为60.8%,2年生存率为22.1%.疼痛缓解率94%(34/36),生活质量明显改善.19例(52.8%)ECOG评分改善.结论 IMRT同步吉西他滨治疗局部晚期胰腺癌近期疗效及患者的耐受良好,生活质量明显改善.
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