神经节苷脂与鼠神经生长因子联合应用对高血压性脑出血患者神经功能、生活质量及实验室指标的影响

摘要

Objective To investigate the influence of nerve nutrition scheme combined therapy on the nerve injury degree,life quality and laboratory index of patients with hypertensive cerebral hemorrhage (HCH).Method One hundred patients with HCH in the period from February 2015 to February 2017 in our hospital were chosen and randomly divided into both group including control group (fifty patients) with monosialotetrahexosyl ganglioside sodium used alone and observation group (fifty patients) with monosialotetrahexosyl ganglioside sodium combined with NGF on the basis of systematic intervention;and the clinical effects,the edema area,the hematoma volume,the NIHSS score,the SIS scores,the Barthel index score,the levels of MMP-9,IL-8,TNF-α,MDA,SOD and MBP before and after treatment of both groups were compared.Results The clinical total effects for short-term of observation group were significantly higher than control group (P＜0.05).The edema area and hematoma volume after treatment of observation group were significantly less than control group and before treatment (P＜0.05).The NIHSS score after treatment of bservation group were significantly lower than control group and before treatment (P＜0.05).The SIS scores and the Barthel index score after treatment of observation group were significantly higher than control group and before treatment (P＜0.05).The levels of inflammatory cytokines,oxidative stress index and MBP after treatment of observation group were significantly lower than control group and before treatment (P＜0.05).Conclusion Nerve nutrition scheme combined therapy in the treatment of patients with HCH can efficiently promote the evacuation of hematoma,control the scope of edema,reduce the damage degree of nerve function,improve the quality of daily life,inhibit the inflammatory reaction and be helpful to deregulate the levels of oxidative stress and MBP.%目的 探讨神经节苷脂与鼠神经生长因子联合应用对高血压性脑出血(HCH)患者神经功能、生活质量及实验室指标的影响.方法 研究对象选取本院2015年2月-2017年2月收治HCH患者100例,以随机数字表法分为对照组(50例)和联合组(50例),分别在对症干预基础上给予神经节苷脂钠单用和鼠神经生长因子联用治疗,比较两组患者临床疗效,治疗前后水肿面积、血肿量、美国国立卫生研究院卒中量表评分(NIHSS)、脑卒中影响量表评分(SIS)、日常生活质量Barthel指数评分(ADL-Barthel)、基质金属蛋白酶-9(MMP-9)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、超氧化物歧化酶(SOD)、丙二醛(MDA)及髓鞘碱性蛋白(MBP)水平等.结果 联合组患者治疗总有效率显著高于对照组(P＜0.05);联合组患者治疗后水肿面积和血肿量均显著小于对照组、治疗前(P＜0.05);联合组患者治疗后NIHSS评分显著低于对照组、治疗前(P＜0.05);联合组患者治疗后Barthel指数和SIS评分均显著高于对照组、治疗前(P＜0.05);联合组患者治疗后炎性细胞因子、氧化应激指标及MBP水平均显著低于对照组与治疗前水平(均P＜0.05).结论 神经节苷脂与鼠神经生长因子联合应用对HCH可有效促进血肿消退,控制水肿范围,减轻神经功能损伤,提高日常生活质量,抑制机体炎症反应,并有助于下调氧化应激指标和MBP水平.