Effect of ganglioside sodium on stress, neural injury degree, rebuilding related factors of neural function and coagulation index in patients with severe craniocerebral injury

摘要

Objective:To investigate the effect of ganglioside sodium on stress, neural injury degree, rebuilding related factors of neural function and coagulation index in patients with severe craniocerebral injury.Methods: From June 2016 to March 2018, 90 cases of severe craniocerebral injury in our hospital were randomly divided into 45 cases of ganglioside sodium group (group GM1) and 45 cases of control group. The levels of stress [including norepinephrine (NE) and cortisol (Cor)], nerve injury [including neuron-specific enolase (NSE), astrocyte-derived protein (S100beta), ubiquitin carboxyl terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP)], nerve function reconstruction [including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)] and coagulation function [including prothrombin time (PT), thrombin time (TT), activated partial prothrombin time (APTT) and fibrinogen (FIB)] were observed and compared between the two groups. Results:Before treatment, there was no significant difference in stress hormone, nerve injury degree, nerve function reconstruction and coagulation function between the two groups.After treatment, the levels of cytokines and FIB in the two groups were significantly higher than those before treatment, and the levels of stress hormone, nerve injury molecule and TT were significantly lower than those before treatment.The levels of cytokines and FIB in GM1 group were significantly higher than those in the control group. The levels of stress hormone, nerve injury molecule and TT in GM1 group were significantly lower than those in the control group. There was no significant difference in the levels of PT and APTT between the two groups before and after treatment.Conclusions: The treatment of severe craniocerebral injury with ganglioside sodium on the basis of routine treatment can relieve body stress and nerve damage, also, facilitate nerve function reconstruction and improve coagulation function.