低密度脂蛋白胆固醇水平与非溶栓性脑梗死出血转化的关系分析

摘要

Objective To study the relationship of low density lipoprotein cholesterol(LDL-C)and non thrombolysis of cerebral infarction and hemorrhagic transformation (HT).Method A retrospective analysis six hundred and thirty seven cases of non thrombolysis in patients with acute cerebral infarction(ACI)during January 2013 to July 2016, 14 days after onset of cranial CT or MRI to discover whether there was bleeding, divided into HT after cerebral infarction group(HT group)and non HT after cerebral infarction group(NHT group);LDL-C 2.6mmol·L-1 was the critical point, LDL-C<2.6mmol·L-1 were groupⅠ, LDL-C≥2.6mmol·L-1 were into groupsⅡ, the incidence of ACI and hemorrhagic transformation would not occur in LDL-c in patients with HT after cerebral infarction were analyzed statistically.Results LDL-C and HT after cerebral infarction group(HT group)and non HT after cerebral infarction group(NHT group)had obvious difference, the study group and control group were significant differences (P<0.05).Conclusion LDL-C was a risk factor for the transformation of non thrombolytic therapy of hemorrhagic cerebral infarction, low density lipoprotein cholesterol and non therapy of HT after cerebral infarction was negatively correlated. The two grade prevention primary prevention, cardiogenic cerebral infarction lipid-lowering therapy of cerebrovascular disease in the hands of the pointer strict clinical is very important in clinic.%目的 探讨低密度脂蛋白胆固醇(LDL-C)水平与非溶栓性脑梗死出血转化(HT)的关系.方法 分析2013年1月至2016年7月在本院住院的637例非溶栓性脑梗死(ACI)患者,发病后14d内复查头颅CT或MRI发现是否有出血,分为脑梗死出血转化组(HT组)及非脑梗死出血转化组患者(NHT组);以LDL-C 2.6mmol·L-1为临界点,LDL-C<2.6mmol·L-1为Ⅰ组,LDL-C≥2.6mmol·L-1为Ⅱ组,将发生HT和NHT患者的LDL-C水平进行差异统计学分析.结果 LDL-C组与HT组及NHT组,存在明显差异(P<0.05).结论 LDL-C是HT的危险因素之一,LDL-C水平与HT呈负相关关系.在临床中严格掌握脑血管疾病的一级预防、心源性脑梗死二级预防的降脂治疗指南十分关键.