目的 探讨脑梗死患者血清同型半胱氨酸(Hcy)、白细胞介素-1(IL-1)、肿瘤坏死因子(TNF-α)与抑郁状态的关系.方法 选取2015年2月至2016年12月在本院治疗的脑梗死患者110例,检测患者血清Hcy、IL-1和TNF-α水平,同时采用汉密尔顿抑郁量表(HAMD-24)评价患者抑郁情况.结果 共有34例患者并发抑郁(抑郁组),76例无抑郁(非抑郁组);抑郁组患者血清Hcy、IL-1和TNF-α水平分别为(18.11±4.22)μmol·L-1、(40.22±3.81)ng·L-1和(37.80±7.10)ng·L-1,明显高于非抑郁组患者(P＜0.05);重度抑郁患者血清Hcy、IL-1和TNF-α水平分别为(23.55±2.06)μmol·L-1、(57.91±3.80)ng·L-1和(58.73±7.05)ng·L-1,明显高于中度抑郁和轻度抑郁患者(P＜0.05);患者抑郁程度与血清Hcy、IL-1和TNF-α呈 正相关(rs=0.611、0.523和0.552,P＜0.05).结论 脑梗死后抑郁患者血清Hcy、IL-1和TNF-α明显升高,可能与脑梗死后抑郁的发生发展有一定的关系,值得进一步研究.%Objective To investigate relationship between serum homocysteine (Hcy), interleukin -1 (IL-1), tumor necrosis factor (TNF-α) in patients with cerebral infarction and depression. Method Selected 110 patients with cerebral infarction in our hospital from February 2015 to December 2016, detected serum Hcy, IL-1 and TNF-α level, used Hamilton Depression Scale (HAMD-24) to assess depression. Results 34 patients were complicated with depression (depression group), and 76 patients without depression (non depression group); The depression group patients serum Hcy, IL-1 and TNF-α were (18.11±4.22)μmol·L-1, (40.22±3.81)ng·L-1and(37.80±7.10)ng·L-1, significantly higher than non depression group (P＜0.05); Severe depression patients with serum Hcy, IL-1 and TNF-α were (23.55±2.06)μmol·L-1, (57.91±3.80)ng·L-1and (58.73±7.05) ng·L-1, was significantly higher than that of moderate depression and mild depression patients (P＜0.05);The degree of depression were positive correlation with serum Hcy, IL-1 and TNF-α(rs=0.611, 0.523 and 0.552, P＜0.05). Conclusion The levels of serum Hcy, IL-1 and TNF-α are significantly increased in patients with depression after cerebral infarction,may be related to the occurrence and development of depression after cerebral infarction, which is worthy of further study.
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