目的：通过应用有创颅内压监护仪，获得持续准确的颅内压数值以及颅内压的变化趋势，揭示颅内压监护在高血压脑出血个体化治疗中的重要指导意义。方法随机选取50例高血压脑出血患者分为监护组（23例）和非监护组（27例）。监护组患者和非监护组患者均频率性应用脱水药物（甘露醇），但监护组患者根据颅内压数值调整脱水药物应用频次和血压值，而非监护组则根据患者的意识状态、影像学资料、瞳孔等变化来调整甘露醇频次和血压值。两组患者入院后均给予相同的内科治疗。比较两组患者手术治疗方式介入的时间、脱水药物（甘露醇）的调整时间、临床转归以及颅内压监护组患者的平均颅内波动水平。结果与非监护组比较，颅内压监测组者手术治疗介入的时间更短（P＜0.05），甘露醇开始减量时间也缩短（P＜0.05），6个月后的GOS评分也提高（P＜0.05）。结论持续颅内压监护能够更加准确地指导手术时机和甘露醇用量的调控，在高血压脑出血的个体化治疗方面有重要意义。%Objective By applying invasive intracranial pressure monitor ,to achieve sustained and accurate intracranial pres-sure values and trends of intracranial pressure ,to reveal important guiding significance of intracranial pressure monitoring in hy-pertensive intracerebral hemorrhage individualized therapy .Methods Fifty cerebral hemorrhage patients in coma were randomly divided into intracranial pressure monitoring group and non-monitoring group ,the non-clinical monitoring patients were treated with conventional therapy ,while for the monitoring of patients ,the times of giving mannitol and the blood pressure were adjus-ted in accordance with the principles of intracranial pressure monitoring .Both groups received same medical treatmant .The time of surgical interventoin ,time adjustment of mannitol ,and the clinical outcome .Results Compared to non-monitoring group ,surgical intervention of intracranial pressure monitoring patients was decrease (P<0.05);monitoring of mannitol of in-tracranial pressure monitoring patients was decrease (P< 0.05) .Conclusion Continuous monitoring of intracranial pressure regulation can guide the timing of surgery and the amount of mannitol more accurately ,and it has a significance in the individu-alized treatment of hypertensive intracerebral hemorrhage .
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