首页> 中文期刊> 《白求恩军医学院学报》 >白芍总苷联合沙利度胺治疗强直性脊柱炎的应用价值及对CRP、ESR、TNF-α的影响

白芍总苷联合沙利度胺治疗强直性脊柱炎的应用价值及对CRP、ESR、TNF-α的影响

         

摘要

目的 探讨白芍总苷联合沙利度胺治疗强直性脊柱炎(ankylosing spondylitis,AS)的应用价值及对CRP、ESR、TNF-α的影响.方法 将150例AS患者随机分为两组,各75例.观察组给予白芍总苷联合沙利度胺治疗,对照组仅采用沙利度胺治疗.对比两组临床疗效、腰背痛指数、外周关节痛指数、晨僵时间、Schober试验、血沉(ESR)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)及不良反应发生率.结果 观察组临床疗效高于对照组(P<0.01);观察组治疗后腰背痛指数、外周关节痛指数、晨僵时间、Schober试验、ESR、CRP及TNF-α均较治疗前显著改善,且观察组改善程度均优于对照组(P<0.01);观察组不良反应发生率16.0%,低于对照组的36.0%(P<0.01).结论 白芍总苷联合沙利度胺治疗AS效果显著,能有效改善CRP、ESR及TNF-α指标,且不良反应少,值得推广.%Objective To investigate the application value of paeony glmcosides and thalidomide in the treatment of ankylosing spondylitis(AS) and the effects on CRP,ESR and TNF-α.Methods One hundred and fifty cases of patients with AS were divided into the observation group and the control group randomly(n=75 in each group).The observation group was treated with paeony glmcosides and thalidomide,and the control group only treated with thalidomide.The clinical efficacy,low back pain index,peripheral joint pain index,time of morning stiffness,schober test,ESR,CRP,TNF-α and incidence of adverse reactions were compared.Results The total effective rate of the observation group(94.7%) was significantly higher than that (69.3%)of the control group (P<0.01).The improvement degree of low back pain index,peripheral joint pain index,time of morning stiffness,Schober test,ESR,CRP and TNF-α of the observation group were significantly better than those control group (P<0.01).The incidence rate of adverse reaction in the observation group(16.0%) was significantly lower than that (36.0%)of the control group(P<0.01).Conclusion Paeony glmcosides and thalidomide in the treatment of AS can effectively improve the CRP,ESR and TNF-α indicators,and with less adverse reactions,and is worth promoting.

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