Ezrin蛋白在食管鳞癌中的表达及其临床意义

摘要

Objective:To investigate the relationship between the expressions of ezrin protein and the invasion and metastasis of esophageal squamous cell carcinoma(ESCC).Methods:The expression of ezrin protein in 76 cases of ESCC and 30 cases of normal esophageal squamous epithelia was detected by using S-P method of immunohistochemical staining,and the results were analyzed with reference to the clinicopathological features.Results:The abnormal expression rates of ezrin protein in ESCC and normal esophageal squamous epithelia were 78.95%(60/76)and 26.67%(8/30),respectively(P<0.01).The abnormal expression of ezrin protein was related to the cell differentiation degree and lymph node metastasis(P<0.05 and P<0.01)in 76 cases of ESCC.Conclusions:The expression of ezrin protein is up-regulated in ESCC,and the overexpression is related to the cell differentiation degree and lymph node metastasis.%目的:探讨食管鳞癌组织中ezrin蛋白的表达及其与肿瘤侵袭和转移的关系.方法:应用免疫组织化学S-P法,检测76例食管鳞状细胞癌组织标本中ezrin蛋白的表达,以30例食管癌旁正常黏膜组织作对照,并结合食管癌的临床病理特征进行分析.结果:ezrin蛋白在76例食管鳞癌中异常表达60例,在30例癌旁正常黏膜中异常表达8例,两者差异有统计学意义(P<0.01).同时ezrin蛋白的异常表达率与食管鳞癌的分化程度和区域淋巴结转移均有一定关系(P<0.05和P<0.01).结论:ezrin蛋白在食管鳞癌中异常高表达,其强阳性表达预示着肿瘤细胞分化程度较差,有淋巴结转移.