食管鳞癌中Ezrin、E-cadherin、CD44v6蛋白表达在肿瘤预后判断价值研究

摘要

Objective To investigate the expressions of Ezrin、CD44v6 and E-cadherin and their correlations with clinic pathological characteristics and prognosis of esophageal carcinoma,and the correlations of Ezrin、CD44v6、E-cadherin.Methods Expressions of Ezrin、CD44v6 and E-cadherin in 70 cases of esophageal squamous cell carcinoma and 21 cases of normal mucous away from cancer and 24 cases of normal esophageal epithelial tissues were detected by SP immunohistochemical staining,and their correlations with clinical-pathological findings were analysed,and all cases were follow-uped.Results The positive rates of Ezrin、CD44v6 and E-cadherin in esophageal squamous cell carcinoma and normal esophageal epithelial tissues were 74.2%(52/70) and 13.3%(6/45),25.7%(18/17) and 75.6%(34/45),78.5%(55/70) and 28.9(13/45),respectively,and the differences were significant(P<0.05).Conclusion Expressions of Ezrin、CD44v6 and E-cadherin were related with occurrence、differentiation、lymphnode metastasis of esophageal squamous cell carcinoma, it has important reference value to detection of three kinds of protein expressions for assessing prognosis of patients.%　　目的：探讨Ezrin、CD44v6、E-cadherin蛋白在食管鳞癌中的表达及其与临床病理和预后的关系,Ezrin、CD44v6、E-cadherin三者的表达在食管鳞癌中的相关性.方法：应用免疫组织化学S-P方法检测Ezrin、CD44v6、E-cadherin蛋白在70例鳞癌组织和21例癌旁组织、24例正常的食管黏膜上皮组织中的表达,分析其与临床病理诸因素的关系,并对所有病例进行随访.结果：Ezrin、E-cadherin及CD44v6在食管鳞癌组织、癌旁和正常黏膜中阳性表达率分别为74.2%(52/70)和13.3%(6/45)、25.7%(18/70)和75.6%(34/45),78.5%(55/70)和28.9%(13/45),差异均有统计学意义(P<0.05).结论：Ezrin、CD44v6、E-cadherin表达均与食管鳞癌的发生、分化及淋巴结转移有关,检测三种蛋白的表达情况对于评估患者预后具有重要的参考价值.