目的:观察ω-3多不饱和脂肪酸(polyunsaturated fatty acids,PUFAs)在重度颅脑外伤并发肺部感染治疗中的应用效果.方法:将56例重度颅脑外伤并发肺部感染的患者随机均分为对照组和干预组,干预组在对照组治疗的基础上加用ω-3PUFAs.2组患者均完善相关检查,常规治疗为抗感染、脱水降颅压等,均建立人工气道(气管插管或气管切开)及机械通气,均给予能量补充105~125 kJ·kg-1·d-1,干预组中部分热量由ω-3PUFAs的脂肪乳剂来提供.分别于治疗前及治疗第2、4、7天监测患者当日最高体温、呼吸频率、心率、白细胞计数及氧合指数,比较2组患者的预后、ICU停留时间、呼吸机使用时间和ICU期间的费用.结果:2组的临床指标在第2天比较差异无统计学意义(P>0.05);2组患者的生命体征和白细胞计数均呈下降趋势,氧合指数呈上升趋势,与时间呈相关性,干预组在第4和7天较对照组更明显,差异均有统计学意义(P0.05);在呼吸机使用时间、ICU停留时间及费用差异均有统计学意义(P 0. 05 ) . The vital signs ( temperature, heart rate,respiration) and white blood cells of the two groups of patients showed downward trend over time, while the oxygenation index showed an upward trend over time,which is more significant for Ewing group on the 4th and 7th day compared with the control group, and the difference was statistically significant ( P 0. 05) . However,in the average ventilator time, ICU length of stay and cost,the two groups has significant differences,with statistical significance ( P <0. 01) . Conclusions:ω-3 polyunsaturated fatty acids on severe brain injury in patients with pulmonary infection in the body has a protective effect.
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