鳞状上皮细胞癌抗原在子宫颈癌患者血清中的诊断价值

摘要

目的:探讨肿瘤标志物鳞状上皮细胞癌抗原(squamous cell carcinoma antigen,SCCAg)在子宫颈鳞癌中的诊断价值,验证化学发光法检测SCCAg的灵敏度和特异性.方法:对经临床验证的140例子宫颈癌患者(病例组)进行血清学SCCAg检测,以150名健康女性作对照.结果:病例组和正常女性对照组的SCC值分别为(21.54±39.95)ng/ml和(0.69±0.42)ng/ml,2组差异有统计学意义(P正常组的x+3s即>1.9 ng/ml为阳性值,则病例组的SCCAg阳性率为86.4%.结论:SCCAg可作为诊断子宫颈癌的特异性指标物,它不仅是有效检测子宫颈癌的方法学之一,并且快速、简便、准确、特异,患者易接受,对患者的疗效观察及预后评价具有重要意义.%Objective:To determine the clinical value of the tumor marker squamous cell carcinoma antigen(SCCAg) in the diagnosis of cervical squamous cell carcinoma and to validate the sensitivity and specificity of chemiluminescence detection of SCCAg. Methods:The serum SCCAg levels in one hundred and forty cervical squamous carcinoma patients and one hundred and fifty healthy women controls were measured by ARCHITECT I2000SR automatic immuno-analyzer. Results: The levels of SCCAg in cervical squamous carcinoma patients and normal controls were (21.54 ± 39.95 )ng/ml and (0.69 ± 0.42 ) ng/ml, respectively. There was a statistically significant difference between the two groups(P ＜ 0.01 ). The positive rate of cervical squamous carcinoma patients was 86.4％ (121/140) when ＞(x) +3s of normal control group( ＞ 1.9 ng/ml) was used as a positive standard. Conclusions:SCCAg can be used as a specific marker in the diagnosis of cervical squamous cell carcinoma. It is a rapid, simple, accurate and specific method, which is also easy to be accepted by patients. Thus, the detection of SCCAg has a very important significance for the curative effect observation and the prognosis evaluation of cervical squamous cell carcinoma.