DIAGNOSTIC VALUES OF COMBINED HEPATOMA-SPECIFIC α-FETOPROTEIN FRACTION AND TELOMERASE IN PATIENTS WITH HEPATOCELLULAR CARCINMA

摘要

Hepatocellular carcinoma (HCC) prognosis is poor and early detection is of the utmost importance. In the present study, the telomerase activities and hepatoma-specific AFP (HS-AFP) levels of peripheral blood we investigated in various kinds of liver disease patients. Our data indicated that the expression of AFP-L3% or telomerase in HCC group was significantly higher (P<0. 01) than that in cirrhosis, chronic hepatitis and normal control group. No significant relationship was found between AFP-L3% or telomerase and Total AFP, except of HCC metastasis and relapse and suggested that quantification of circulating telomerase expression and AFP-L3 level are overexpressed in HCC, indicated that the analysis of AFP-L3% or telomerase are useful markers to diagnose and differentiate HCC or monitor metastasis and relapse of HCC.