高频电波刀电切术联合α-干扰素栓治疗子宫颈上皮内瘤变伴高危型人乳头瘤病毒感染的临床观察

摘要

目的:观察高频电波刀电切术(LEEP)联合干扰素栓治疗子宫颈上皮内瘤变(CIN)伴高危型人乳头瘤病毒(HPV)感染的临床疗效.方法:将126例诊断为CIN的患者随机分为观察组和对照组,每组63例.2组患者均行杂交捕获Ⅱ代(HC-Ⅱ)试验后进行LEEP治疗,手术标本送病理检查,观察记录手术时间、创面愈合时间及各种术后并发症的发生率.术后观察组联合使用α-干扰素栓治疗,对照组术后不需特殊治疗.术后随访12个月,比较2组术后6个月及12个月HPV阳性率.结果:2组的手术时间、术后创面愈合时间、术后并发症发生率差异均无统计学意义(P>0.05).随访6个月,观察组CIN治愈率为98.4%,对照组为88.9%,2组差异无统计学意义(P>0.05).2组术后6个月、12个月HPV阳性率分别为6.3%、30.2%和3.2%、23.8%,差异均有统计学意义(P 0. 05 ) . The cure rates of the observation and control group were 98.4% and 88. 9 % respectively, which were not statistical significant ( P > 0. 05 ) in 6 months after surgery. The HPV-positive rates of the observation and control group were 6. 3% and 30. 2% ,and 3. 2% and 23. 8% in 6 and 12 months after surgery respectively, which were statistical significant ( P < 0. 01). Conclusions: LEEP combined interferon treatment can inhibit the HPV infection and reducing the recurrence of CIN.