Objective: To observe the effects on marzulene combined with omeprazole, amoxicillin and clarithromycin in the treatment of peptic ulcer and eliminating the infection of Helicobacter pylori ( Hp) . Methods: One hundred and fifty-eight peptic ulcer patients (including gastric ulcer and duodenal ulcer) were diagnosed by gastroscope, and their rapid urease tests were positive. All patients were randomly divided into treatment group ( 80 cases) and control group ( 78 cases). All patients took 20 mg omeprazole, 1. 0 g amoxicillinand and 0. 5 g clarithromycin twice a day for 14 days by oral. The treatment groups were added 0. 67 g of marzulene three times a day for 14 days. The ulcer healing and Hp clearance rates of all patients were observed by gastroscope and rapid urease test. Results:The ulcer healing and Hp clearance rates of the treatment and control group were 92. 50% & 87. 50% vs 67. 95% & 60.26% , respectively, the differences on statistic were significantly ( P < 0. 01 ) . Conclusions: The effects and Hp clearance rates of marzulene combined with omeprazole, amoxicillin and clarithromycin in the treatment of peptic ulcer are befter and highe, this is a safe and effective therapy way.%目的:观察谷氨酰胺呱仑酸钠、奥美拉唑、阿莫西林、克拉霉素联合治疗消化性溃疡及根除幽门螺杆菌(Hp)感染的疗效.方法:选择经电子胃镜确诊为消化性溃疡(包括胃溃疡和十二指肠溃疡)且快速尿素酶试验阳性的患者158例,随机分为治疗组80例和对照组78例.2组患者每天2次口服奥美拉唑20 mg、阿莫西林1.0 g、克拉霉素0.5 g,其中治疗组加谷氨酰胺呱仑酸钠0.67 g,每天3次口服.2组同时进行正规治疗14 d,4周后复查电子胃镜和快速尿素酶试验,观察溃疡愈合率和Hp清除率.结果:治疗组溃疡愈合率92.50%,Hp清除率87.50%;对照组溃疡愈合率67.95%,Hp清除率60.26%,差异均有统计学意义(P
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