Objective: To compare the effects and adverse reactions of flurbiprofen axetil combined with fentanyl in radical mastectomy for breast cancer postoperative intravenous analgesia. Methods: Sixty cases of breast cancer patients after operation treated with patient-controlled intravenous analgesia ( PCIA) were randomly divided into two groups, 30 cases in each group, group Ⅰ , postoperative analgesia with fentanyl was given fentanyl 1.0 mg and ondansetron hydrochloride injection in 8 mg and normal saline 100 ml;group Ⅱ was given lurbiprofen axetil 50 mg before skin suture, postoperative analgesia was given fentanyl 0. 5 mg and lurbiprofen axetil 250 mg and ondansetron injection 8 mg and normal saline 100 ml. Two groups of PCIA pump set the same:maintenance dose of 2 ml/h,a single dose of 0. 5 ml,locking time 15 min. Analgesia,sedation scores and the incidence of adverse reactions of two groups were observed in 12,24,48 hour. Results:Except for group Ⅱ less than group Ⅰ (P 0. 05 ) ; group Ⅱ adverse reaction rate(20. 0% ) was lower than in group Ⅰ (46.7% ) (P 0.05);Ⅱ组不良反应发生率20.0%低于Ⅰ组46.7%(P<0.05).结论:氟比洛芬酯复合芬太尼用于乳腺癌根治术术后静脉镇痛效果与单纯芬太尼相似,但不良反应发生率明显降低.
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