尿白蛋白/肌酐比值在2型糖尿病早期肾损伤中的应用

摘要

Objective:To explore the correlation of the ACR of morning and random urine and 24 hour urinary albumin(24 h UA), and the application of random urinary ACR replacing 24 h UA in screening the early renal injury of type 2 diabetic patients. Methods:The morning and random urine of 89 type 2 diabetic patients were collected,the diagnostic sensitivity and specificity and correlation of the ACR of morning and random urine and 24 h UA was compared. The curves of ACR and ROC of morning and random urine were established using the standard of 24 h UA,the area under the ROC curve was compared. Results:The ACR of morning and random urine were 9. 02 and 8. 65 mg/mmol,the difference of which was not statistically significant(P>0. 05). The ACR in morning urine and random urine was positive correlation(r =0. 951,P 0. 05). Conclusions:The random urine ACR is good correlation with 24 h UA,which can replace 24 h UA in screening and monitoring the early renal injury of type 2 diabetic patients.%目的：研究2型糖尿病患者晨尿和随机尿中白蛋白/肌酐比值(ACR)与24 h尿白蛋白(24 h UA)的相关性,探讨采用随机尿ACR替代24 h UA用于2型糖尿病早期肾损伤筛查的应用价值。方法：收集89例2型糖尿病患者24 h尿及晨尿和随机尿标本,比较晨尿和随机尿ACR与24 h UA的相关性、诊断敏感度及特异度；同时以24 h UA为标准,建立晨尿和随机尿ACR的受试者工作特征曲线(ROC曲线),并比较ROC曲线下面积。结果：晨尿及随机尿ACR分别为9.02及8.65,差异无统计学意义(P>0.05)。随机尿与晨尿ACR呈高度相关关系(r=0.951,P0.05)。结论：随机尿ACR具有标本留取简便、与24 h UA相关性较好等特点,可以替代24 h UA作为2型糖尿病早期肾损伤的筛查及监测指标。