慢性阻塞性肺疾病患者血浆肾上腺髓质素水平的变化

摘要

Objective:To observe the level of the plasma adrenomedullin ( ADM ) in patients with chronic obstructive pulmonary disease( COPD) ,and investigate the correlation of ADM with COPD. Methods:The patients with COPD were divided into the acute exacerbated COPD group and stable COPD group,and the healthy people were set as the control group(23 cases each group). The plasma ADM levels,pulmonary function,blood gas analysis and blood routine test among three groups were compared. Results:The levels of plasma ADM in acute exacerbated COPD group and stable COPD group were significantly higher than that in control group (P<0. 01),and which in acute exacerbated COPD group was significantly higher than that in stable COPD group(P<0. 01). The level of plasma ADM was significantly negative correlation with the FEV1. 0%,FEV1. 0/FVC% and arterial oxygen partial pressure(P<0.01),but which was correlation with pH value(P < 0. 05). Conclusions:With the deterioration of COPD patients,the ADM compensatory increasing can expand the airway,inhibit the inflammation reaction and delay disease progression.%目的：：通过检测慢性阻塞性肺疾病( COPD)患者血浆肾上腺髓质素( ADM)的水平,研究ADM与COPD病情变化的相关性。方法：选择COPD急性加重期患者(加重组)、稳定期患者(稳定组)及健康体检者(对照组)各23例,检测并比较其血浆ADM水平、肺功能、血气分析、血常规。结果：加重组与稳定组血浆ADM水平均明显高于对照组(P<0.01),而加重组血浆ADM水平亦显著高于稳定组(P<0.01)；血浆ADM水平与FEV1.0%、FEV1.0/FVC%和动脉血氧分压均呈显著负相关关系(P<0.01),而与血pH有相关关系(P<0.05)。结论：随着COPD患者病情恶化,ADM代偿性增加,扩张气道,抑制炎症反应,可延缓疾病进展。