沙利度胺联合GP方案治疗晚期三阴性乳腺癌疗效观察

摘要

Objective:To explore the curative effects and adverse reactions of GP combined with thalidomide in the treatment of advanced triple-negative breast cancer. Methods:A total of 58 patients with advanced triple-negative breast cancer were randomly divided into the GP combined with thalidomide group(combination group) and GP group(chemotherapy group)(29 cases each group). The curative effect,adverse reaction,tumor marker and median survival time( MST) between two groups were compared. Results:The effective rate in combination group(58. 62%) was higher than that in chemothreapy group(31. 03%) (P 0. 05),other adverse rections were not obvious. Conclusions:GP combined with thalidomide in treating advanced triple-negative breast cancer is good curative effect and mild adverse reactions,which is worthy of promotion.%目的:探讨沙利度胺联合GP方案治疗晚期三阴性乳腺癌的临床疗效及不良反应.方法:对58例晚期三阴性乳腺癌随机分为沙利度胺联合GP方案组(联合组)和GP方案组(化疗组),比较2组的疗效、不良反应、肿瘤标志物及病人生存时间.结果:联合组有效率58.62%,高于化疗组的31.03%(P0.05),其余不良反应不明显.结论:沙利度胺联合GP方案治疗晚期三阴性乳腺癌疗效肯定,不良反应轻,值得临床进一步推广.