单药治疗癫痫患者停药后复发的高危因素分析

摘要

目的:分析经单药治疗后病情完全控制并停药的癫痫患者1年内病情复发情况,并对诱导复发的高危因素进行分析.方法:选取130例癫痫患者作为研究对象,均为经单药治疗后病情完全控制,停药后对患者进行1年以上的随访,记录癫痫复发情况,并分析引起癫痫复发的危险因素.结果:130例癫痫患者经单药治疗病情完全控制并停药后1年内复发率为40.00%(52/130);单因素分析结果显示,治疗前癫痫每年发作>5次、初始治疗前病程>1年、病程中存在癫痫持续状态、颅内有病灶、停药前有痫性放电、减停药前无发作时间5次、初始治疗前病程>1年、颅内有病灶、停药前有痫性放电、减停药前无发作时间<4年、减药时间<6个月是造成停药后癫痫复发的高危因素(OR=2.976~8.742,P<0.05).结论:单药治疗癫痫停药复发的危险因素较多,针对高危因素采取针对性干预措施有助于减少复发.%Objective:To analyze the epilepsy recurrence within 1 year after stopping drug in complete control patients treated with monotherapy,and high risk factors of inducing relapse. Methods:The drug was stopped in 130 epilepsy patients with monotherapy after the disease was completely controlled. The patients were followed up at least 1 year after stopping drug,and the epilepsy recurrence was recorded. Results:The recurrence rate within 1 year after stopping drug was 40. 00%(52/130) in 130 epilepsy patients treated with monotherapy. The univariate analysis showed that the epileptic seizure was more than 5 times 1 year,the duration was more than 1 year before treatment, and the status epilepticus and intracranial lesions during the disease, epileptic discharge before stopping drug, no-attack time less than 4 years before reducing and stopping drug, high epilepsy relapse rate after stopping drug in patients with reducing drug time less than 6 months were found(P<0. 05 to P<0. 01). Multivariate logistic regression analysis showed that the epileptic seizure more than 5 times 1 year,duration more than 1 year before treatment,intracranial lesions,epileptic discharge before stopping drug,no-attack time less than 4 years before stopping and reducing drug time less,and reducing drug time less than 6 months were the high risk factors of epilepsy relapse(OR=2. 976 to 8. 742,P<0. 05). Conclusions:The risk factors of the epilepsy recurrence in patients treated with monotherapy after stopping drug are more,taking appropriate intervention measures can reduce the recurrence of epilepsy.