Objective To analyze the high-risk factors of epilepsy recurrence after withdrawal of monotherapy so as to pro-vide reference for the clinical treatment of epilepsy. Methods 100 cases with epilepsy admitted in our hospital from June 2012 to June 2015 were randomly selected as the subjects. All the patients were treated by monotherapy without the onset of epilepsy within 2 years. The patients were followed up for 3 years. The effect of gender, the initial treatment time of epilepsy, seizure frequency, mode of onset, attack etiology, and intracranial lesions on the epilepsy recurrence was analyzed. Results Of the 100 cases with epilepsy, 34 cases had recurrence, the recurrence rate was 34%. The pre-treatment mode of onset, seizure frequency, initial treatment time of epilepsy, intracranial lesions were the factors affecting the epilepsy recur-rence(P<0.05). 41.18%of the patients with epilepsy recurrence had no significant incentives, and the epilepsy recurrence of other cases was related to unstable emotion, living habits and infection and so on. Conclusion Many high-risk factors can cause the epilepsy recurrence after withdrawal. Effective avoidance of high-risk factors can reduce the epilepsy recurrence rate.%目的：对单药治疗癫痫者停药后复发的高危因素进行分析,为临床治疗癫痫提供参考依据。方法随机选取2012年6月—2015年6月该院收治的100例癫痫患者作为研究对象，所有患者均进行单药抗癫痫治疗且近2年内未癫痫发作。对患者进行3年随访，分析患者的性别、癫痫发病后起始治疗时间、发作频率、发作形式、发作病因、颅内有无病灶等因素对患者复发的影响。结果100例患者中，34例复发，复发率为34%。影响癫痫复发的因素包括治疗前的癫痫发作形式、发作频率、癫痫发病后起始治疗时间、颅内有无病灶（P＜0.05）。复发患者中，41.18%的患者没有明显诱因，其他患者复发均与情绪不稳定、生活习惯、感染等情况有关。结论癫痫患者停药后复发的高危因素有很多，对高危因素进行有效规避可降低癫痫的复发率。
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