目的：采用磁共振弥散张量成像技术（DTI），无创观测复健片对缺血性脑卒中颈髓皮质脊髓束重塑的修复作用，并评估其对运动功能恢复的重要意义。方法收集符合纳入标准的60例病例，随机分为治疗组和对照组，各30例。两组患者都给予常规西药治疗，治疗组患者同时给予中药复健片。在治疗前和治疗后，均对60例患者各进行1次 ADL 评分、CSS 评分及颈髓的 DTI 检测，并分析两组患者 DTI 数据与 CSS 评分之间的相关性。结果研究显示，与对照组比较，治疗组患者的日常生活能力、临床神经功能缺损恢复程度改善更明显（P ＜0．01），治疗组患者治疗后的 DTI数据明显低于治疗前的 DTI 数据（P ＜0．01），且较对照组改善明显（P ＜0．01），两组患者的 CSS 评分与△FA 值均存在显著的正相关性（P ＜0．01），且治疗组的 CSS 评分与△FA 值的相关系数比对照组高。两种治疗方案对血液常规、肝功能、肾功能均未产生不良影响。结论复健片能够促进皮质脊髓束修复，明显改善患者运动功能且不增加服药风险。%Objective Based on diffusion tensor imaging (DTI)technology,to noninvasively evaluate the remodeling effect of Fujian Tablet on corticospinal tract of patients with cerebral ischemic stroke (CIS)by taking activities of daily living(ADL)score and Chinese stroke scale (CSS)score as the indi-cators,and to assess the significance of recovery of patients’motor function.Methods 60 cases accord-ing to the inclusive criteria were randomly divided into control group and treatment group (each n =30). All patients took conventional western medicine,in addition,those in treatment group took orally Fujian Tablet for 60 days.Before and after treatment,CSS score and ADL score were recorded,and the cortico-spinal tract was detected by using DTI.Then the correlation between data from DTI and CSS score were analyzed.Results Improvement of patients’activities in daily life,recovery of neurological damage in treatment group were superior to those in the control group (P <0.01).And after treatment,DTI data in the treatment group was much less than that before (P <0.01 ),the improvement showed significance compared with the control group (P <0.01).The positive correlation of CSS score and △FA was proved in both groups(P <0.01 ),with the correlation coefficient of the treatment group higher.Furthermore, no adverse effects were found in indicators of the routine blood test,liver function and kidney function. Conclusion Fujian Tablets could promote the remodeling of corticospinal tract and improve the motor function of CIS patients without increasing the risk of taking more drugs.
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