Objective To investigate the pathogenesis,clinical manifestations,radiologic features and treatment pro-tocol in patients with Wernicke’s encephalopathy or Marchiafava-Bignami disease secondary to chronic alcoholism,malnu-trition and so on.Methods Here we presented 4 typical cases,including the clinical manifestations,laboratory tests,treat-ment and outcome,among which two are Wernicke’s encephalopathy,the other two are Marchiafava-Bignami disease.Re-sults On the basis of case reports and literature review,the mechanism,clinical features,imaging characteristics and treat-ment strategy were analyzed.Conclusion Chronic alcoholism and malnutrition may be the two main causes for Wernicke’ s encephalopathy and Marchiafava-Bignami disease through complex mechanisms,to which should be paid enough attention on clinic.Taking into consideration of its emergency,it is of importance for early diagnosis.%目的：探讨慢性酒精中毒、营养不良等因素致 Wernicke’s encephalopathy 和 Marchiafava－Bignami disease 的发病机制、临床表现、影像特点及治疗方案。方法报道4例典型病例，其中2例为 Wernicke’s encepha－lopathy，2例为 Marchiafava－Bignami disease，并总结复习了相关文献。结果结合4例典型病例和文献复习，总结分析了 Wernicke’s encephalopathy 和 Marchiafava－Bignami disease 的发病机制、临床表现、影像特点及治疗方案。结论慢性酒精中毒、营养不良等因素可通过多种机制导致 Wernicke’s encephalopathy 和 Marchiafava－Bignami disease，临床上应予以重视。考虑到两病均为急症，早期诊断显得尤为重要。
展开▼
