Objective To investigate the relationship between GABAARG 2 gene and drug-resistant epilepsy in pa-tients with epilepsy .Methods According to the reactivity of the anti epileptic drugs ,98 patients with epilepsy were divid-ed into two groups:drug-resistant group ( observation group ) and sensitive group ( control group ) ,there were 46 patients in the observation group and 52 patients in the control group .DNA of all patients was extracted and the probability of occur-rence of GABAARG2 gene was determined by PCR gene sequencing .For each subject , oral antiepileptic drug phenytoin ( Phenytoin) was taken to compare the oral absorption rate of drugs of two groups of patients .Results There was no signif-icant difference in age ,sex,past history and status of persistent disease between observation group and control group ( P>0.05).But the probability of GABAARG2 gene in the observation group was significantly higher than that in the control group,the difference was statistically significant (χ2 =8.08,P=0.01).The total oral absorption rate of the observation group (68 .71%±12.28%) was significantly lower than that of the control group (82.36%±15.31%),the difference was statistically significant (χ2 =6.78,P=0.01).Conclusion GABAARG2 gene expression in the brain will affect the effect of antiepileptic drugs ,it has good reference value for drug resistance in patients .%目的：探讨癫痫患者中GABAARG2基因与耐药性癫痫的关系。方法选择来本院就诊的98例癫痫患者，根据对抗癫痫药物的反应性分为耐药组（观察组）46例和敏感组（对照组）52例进行研究，提取所有患者的DNA，采用PCR基因测序鉴定GABAARG2基因出现的概率，对每一位受试者以口服传统的抗癫痫药物-苯妥英（phenytoin）方式来对比两组患者的药物口服吸收率。结果观察组和对照组之间的年龄、性别、既往病史、持续状态方面差异均无统计学意义（ P＞0．05）。观察组出现GABAARG2基因的概率显着高于对照组，差异具有统计学意义（χ2＝8．08，P＝0．01）；观察组的总体口服吸收率（68．71％±12．28％）明显低于对照组的口服吸收率（82．36％±15．31％），差异具有统计学意义（χ2＝6．78，P＝0．01）。结论 GABAARG2基因的在脑内的出现会影响抗癫痫药物的效果，进而引起患者的耐药性，对临床治疗有较好的参考价值。
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