IL-35及其免疫调节作用与妊娠免疫耐受的关系

摘要

The discovery of the novel inhibitory cytokine and research of biological functions have helped us re- veal the relation between antigen - presenting ceils and adaptivity of immune system ( immune tolerance). IL - 35 was a newly discovered and unique immunosuppressive cytokine, which belonged to IL- 12 cytokine family, and had obviously suppressive effect on many immune cells and cytokines, participating in mediate immune toler- ance. This article summarized the structure, receptor and immunosuppressive function of IL - 35 and the relation with pregnancy immune tolerance.%新型抑制性细胞因子的发现及生物学功能的研究有助于揭示抗原提呈细胞和机体免疫系统适应性（即免疫耐受）之间的密切关系。IL-35（白细胞介素-35）是新发现的一种独特的免疫抑制性细胞因子，属于IL—12细胞因子家族，主要由活化的调节性T细胞分泌，对多种免疫细胞和细胞因子均有明显的抑制作用，参与介导机体免疫耐受的形成。本文对IL-35的结构、受体、免疫抑制作用及其与妊娠免疫耐受形成之间的关系进行了综述。