甲硝唑高分子载体药物及纳米微球的合成与表征

摘要

将常用的硝基咪唑类的抗阿米巴药物甲硝唑制成可聚合的含药单体,进而利用自聚、共聚和乳液聚合,合成了一系列含甲硝唑高分子药物及高分子药物纳米微球,并用1H-NMR,IR,GPC和TEM等检测手段对产物进行了表征.%In this paper, the monomer was prepared by means of the reaction of metronidazole and methacrylyl chloride. Polymeric drug and nano-microsphere containing metronidazole were obtained via homopolymerization, copolymerization and emulsion polymerization, respectively. Synthetic products were characterized with 1 H-NMR,IR, GPC and TEM.