Macromolecular Drug Conjugates, Metronidazole-Cyclodextrin Prodrugs

摘要

The antimicrobial drug metronidazole was covalently attached to e-cyclodextrin by --CH2-CO-bridges. The preliminary release behavior of metronidazole in the cecal fluids of rats was studied at 37 °C. Metronidazole was nearly released 60% from the macromolecular conjugates after 24 h in the cecal fluids of rats, probably via the biodegradation by glycosidases and hydrolases.