An accurate understanding of the molecular events governing pancreas development can have an impact on clinical medicine related to diabetes,obesity and pancreatic cancer,diseases with a high impact in public health. Until 1996,the main animal models in which pancreas formation and differentiation could be studied were mouse and,for some instances related to early development,chicken and Xenopus. Ze-brafish has penetrated this field very rapidly offering a new model of investigation; by joining functional genomics,genetics and in vivo whole mount visualization,zebrafish has allowed large scale and fine multidimensional analysis of gene functions during pancreas formation and differentiation. The early pancreas development and morphogenesis of zebrafish were introduced.%准确理解发育过程中的分子事件从而调控胰腺发育,对临床医学相关的糖尿病、肥胖、胰腺癌和疾病有着重要影响.1996年以前,胰腺发育和分化研究的主要动物模型是老鼠和与早期发育相关的鸡和爪蟾.斑马鱼作为一个新的研究模型,通过参与功能基因组学、遗传学和体内全胚胎观察,斑马鱼已经大范围应用和基因功能的多维度定义在胰腺的形成和分化过程中.主要介绍了模式动物斑马鱼早期胰腺发育和形态建成.
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