早期肝脏发育研究进展

摘要

The liver is the largest internal organ and it provides many essential metabolic, exocrine and endocrine functions. Hepatocytes are the principal cell type in the liver and these along with biliary epithelial cells are derived from the embryonic endoderm. Embryological experiments in animal models have demonstrated that liver development occurs through a progressive series of reciprocal tissue interactions between the embryonic endoderm and nearby mesoderm. The current molecular pathways controlling liver and biliary system development in the mouse embryo are summarized.%肝脏是体内最大的一个器官,对于维持体内新陈代谢具有重要作用,具有内分泌和外分泌的功能.肝细胞是肝脏内部的主要细胞,它和胆表皮细胞一起起源于胚胎内胚层在动物模型中的胚胎试验表明肝脏发育伴随着一系列来自胚胎内胚层和邻近的中胚层相互作用的信号调节.主要总结了在小鼠中控制肝脏发育的一些分子途径.