首页> 中文期刊> 《安徽农业科学》 >紫金龙总提取物对吗啡依赖小鼠戒断症状的影响

紫金龙总提取物对吗啡依赖小鼠戒断症状的影响

         

摘要

The paper studied the morphology and physicochemical characters of the young seedlings of rapeseed Zhongyou 821 which could endure low phosphorus content under phosphorus sufficiency and deficiency. As indicated by the result, the morphology of rapeseed. Zhongyou 821 under phosphorus deficiency was quite different from that of the control. The euphylla of the aboveground part grew very slow, and the plant was short, the leaf was small and the petiole was thick. The underground taproot was thin and weak; as shown by the Apase activity detection of young rapeseed root, after phosphorus deficiency treatment, the Apase activity increased significantly and improved with the extending stress time. The change of Apase activity reflected the adaptive response of rapeseed root to low phosphorus stress. As indicated by the POD and CAT activity detection of the rapeseed leaf blade under phosphorus stress, both of them increased significantly at the primary stage of phosphorus stress, but with the increasing treatment time, the POD activity decreased gradually, while the catalase activity experienced no significant change.%[目的]观察紫金龙总提取物对吗啡依赖小鼠戒断症状的影响.[方法]以连续递增剂量方式皮下注射盐酸吗啡建立吗啡依赖小鼠模型,灌胃不同剂量(150、300、600 mg/kg)的紫金龙总提取物40 min后,用纳络酮(4 mg/kg)腹腔注射催瘾.[结果]紫金龙总提物低、中、高剂量组对吗啡依赖小鼠戒断跳跃症状有抑制作用(P<0.05);对扭体症状具有显著抑制作用(P<0.01);对小鼠体重减少症状具有抑制作用(P<0.05),并且中、高剂量组效果显著(P<0.01);然而仅低、中剂量组对小鼠抓脸的戒断症状有抑制作用(P<0.05),其中中剂量组效果显著(P<0.01),而高剂量组与自然戒断组比较无显著性差异.[结论]紫金龙总提取物在一定程度上可缓解吗啡依赖小鼠戒断症状.

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