中剂量螺旋藻多糖和银杏提取物的联合抗衰老作用研究

摘要

[ Object ] To investigate the joint anti-aging effect of middle dosage Spirlina platensis polysaccharide (PSP) and Ginkgo biloba extract (GBE). [ Method ] The aging mice were induced by injecting 125 mg/kg D-galactose for 42 d, and the mice in medicine group were fed with 100 mg/kg PSP, GBE and PSP-GBE joint medicine liquid respectively, then the weight of immune organs, SOD activity and MDA contents were determined. [ Result ] PSP and GBE worked efficient in anti-aging, and the joint treatment was endowed with the strongest anti-aging effect. [ Conclusion] The study provides scientific basis for the joint anti-aging effect of PSP and GBE.%[目的]研究中剂量螺旋藻多糖和银杏提取物的联合抗衰老作用.[方法]每天对试验小鼠颈下注射D-半乳糖125 mg/kg,连续42d,建立衰老模型.给药组小鼠每天灌服100 mg/kg螺旋藻多糖、银杏叶及复合药液,观察中剂量复合螺旋藻多糖和银杏叶有效成分对D-半乳糖致衰老小鼠的作用,并测定免疫器官重量、血清SOD活性和心肌、脑丙二醛(MDA)含量等相关衰老指标.[结果]螺旋藻多糖和银杏提取物均能有效对抗D-半乳糖所致小鼠衰老,二者的复合药效要强于单一药效.[结论]该研究为螺旋藻多糖和银杏提取物的联合抗衰老作用提供了试验依据.