[ Objective ] The research aimed to provide basis for treatment and resources utilization of fungi residue from tetracycline production.[ Method ] The fungi residue from tetracycline production and wheat bran of different proportions were used as culture medium resp., the fungi residue from tetracycline production was treated through synergism fermentation with black mold, Trichoderma koningii and viridin,the residual antibiotics in fungi residue was degraded while producing compound enzyme. [ Result] Through aerobic fermentation for 96 h under the condition with proportion of fungi residue from tetracycline production to wheat bran as 7:3 ,water content of medium as 50％ ,medium thickness as 10 cm and culture temperature at 25 ～30 ℃ ,the compound enzyme containing abundant cellulase,xytase,β-glucolase and acid protease was yielded and the degraded rate of residual tetracycline in fungi residue could reach 97.3％. [ Conclusion] The optimum degradation condition of residual antibiotics in fungi residue from tetracycline production was confirmed through this research.%[目的]为四环素菌渣的处理及资源化利用提供依据.[方法]分别以不同比例四环素菌渣和麸皮为培养基,利用黑曲霉、康宁木霉和绿色木霉协同发酵处理四环素菌渣,在生产复合酶制剂的同时降解菌渣中残留的抗生素.[结果]在四环素菌渣:麸皮=7:3,培养基水分50%,厚度10 cm,培养温度25～30℃条件下好氧发酵96 h,可得到富含纤维素酶、木聚糖酶、β-葡萄糖酶和酸性蛋白酶的复合酶制剂,且菌渣中残留四环素的降解率可达97.3%.[结论]该研究确定了四环素菌渣中残留抗生素的最佳降解条件.
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