[目的]应用“仔猪腹泻康”新兽药对80头仔猪的黄痢进行临床疗效试验,为推广新兽药提供科学依据.[方法]将自然感染确诊为仔猪黄痢的病猪80头随机分为4组,每组20头.药物的高、中、低剂量组分别每头灌服5.0、3.5、2.0g“仔猪腹泻康”,药物对照组灌服3.5 g白头翁散,每天2次,连续3d.给药后每天观察病猪,记录精神、食欲和下痢情况,观察至停药后第7天统计疗效；分别于给药前和停药后第2天采集血样测定血红蛋白(Hb)、红细胞(RBC)总数、白细胞(WBC)总数的变化.[结果]“仔猪腹泻康”高、中剂量组的治愈率分别为95％、85％,显著高于药物对照组(70％)和药物低剂量组.药物高、中剂量组的病猪数迅速减少,症状迅速减轻,高剂量组的治愈率和总有效率最高,治疗后各组Hb含量和RBC总数有所升高、WBC有所降低,但无显著性差异(P＞0.05).[结论]“仔猪腹泻康”高、中剂量组对仔猪黄痢有较好的疗效,推荐中剂量(3.5g/头)为临床应用剂量.%[ Objective ] In order to provide the scientific basis, the curative effect of Zizhufuxiekang was observed for 80 clinical piglets with diarrhea dysentery. [ Method ] 80 piglets yellow scours of natural infection were selected and divided into four groups randomly, each group 20. The high, middle and low-dose drugs group were fed 5 g, 3.5 g, 2 g Zizhufuxiekang orally respectively, the control drug group was fed 3.5 g Baitouwengsan, 2 times a day, 3 d. The spirit, appetite and diarrhea cases of pigs were observed after stopping drug until 7 days; the total number of blood hemoglobin (Hb) , red blood cell (RBC) , white blood cell (WBC) was determined before medication and stopping medication after 2 days respectively. [ Result ] The cure rates of high-dose drugs group and middle-dose drugs group of Zizhufuxiekang was 95% , 85% respectively, it is higher significantly than control drugs group (70% ) and low-dose drugs group. The number of disease of pigs in high-dose drugs group and middle-dose drugs group decreased rapidly and symptoms reduced quickly. The cure rate and total effective treatment of high-dose drugs group is the highest. The Hb levels and RBC levels in high-dose drugs group and middle-dose drugs group were increased , and the WBC levels was decreased, but no significant difference ( P > 0.05). [ Conclusion] It had good treatment of high-dose drugs group and middle-dose drugs group of Zizhufuxiekang in piglet yellow scours, the dose (3. 5 g/head) for clinical application was recommended.
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