翻译调节肿瘤蛋白(TCTP)与细胞生长调控

摘要

翻译调节肿瘤蛋白(translationally controlled tumor protein,TCTP)是一个在物种间高度保守、广谱表达和多功能的蛋白质,具有调节细胞骨架的动态变化和调节细胞的生长与增殖的作用；能够激活干细胞标记基因Oct4和Nanog的转录；调节细胞凋亡、肿瘤逆转、细胞分化、炎症反应和保护细胞免受多种应激的损伤等.本文综述了TCTP的结构、表达调控、生物学功能等研究进展.%The translationally controlled tumour protein (TCTP) is a highly conserved protein and appears to be widely expressed in all eukaryotic organisms. TCTP is a multifunctional protein, including many cellular processes, e.g. Cytoskeleton regulation, cell growth and proliferation, apoptosis, tumor reversion, cell differentiation, inflammatory response and protection of cells against various stress conditions. TCTP is also a transcription factor for pluripotency genes Oct4 and Nanog. This review focuses on TCTP expression regulation and its biological functions.