Objective To explore the clinical implementation of reliable methods of intensive insulin therapy in type 2 diabetic pa-tients,in order to provide reference basis for the clinical treatment of type 2 diabetes and related research. Method All patients in this study were type 2 diabetic patients,all patients in 110 cases. The patients were divided into the observation group(55 cases)and control group (55 cases)at random. The observation group was treated with insulin detemir and insulin aspart treatment,control group using synthetic hu-man Neutrul Insulin Injection R and synthesis of human Neutrul Insulin Injection N treatment. The research object was compared between the two groups before and after treatment to observe the different FPG,2h - PPG,the average recovery time,blood glucose insulin dosage, incidence of hypoglycemia. Results The implementation of different treatment methods,two indicators of two groups of patients with FPG,2h- PPG were improved in different degree,comparative data on the differences between before and after treatment group were statistically sig-nificant(P < 0. 05);implementation of the treatment group,two patients from two indexes of water level difference,the difference was not statistically significant(P > 0. 05);the average recovery time,comparison between groups,the patients in observation group index lower,with statistical significance of the data and the difference between groups(t = 10. 0905,P = 0. 000 0);in blood glucose,insulin dosage,compar-ison between groups,the patients in observation group index less,with statistical significance of data and the difference between groups(t =5. 882 8,P = 0. 000 0);the incidence of hypoglycemia,comparison between groups,the patients in observation group index lower,with sta-tistical significance of the data and the difference between groups(χ2 = 4. 949 5,P = 0. 026 1). Conclusion In clinical practice for patients with type 2 diabetes mellitus practice process,using insulin detemir and insulin aspart implementation of clinical treatment effect is better, higher reliability.%目的：为了进一步探讨临床针对2型糖尿病患者实施胰岛素强化治疗的可靠方法，为2型糖尿病的治疗和相关研究提供借鉴依据。方法：2型糖尿病患者110例，随机分成观察组（55例）和对照组（55例）。观察组采用地特胰岛素和门冬胰岛素实施治疗，对照组采用合成人胰岛素注射液 R 和合成人胰岛素注射液 N 实施治疗。观察比较两组研究对象采用不同治疗方案前后的 FPG、2h - PPG、平均血糖达标时间、血糖达标时胰岛素用量、低血糖事件发生率。结果：实施不同治疗方法后，两组患者的 FPG、2h - PPG 两项指标均得到了不同程度的改善，组内治疗前后比较差异均具有统计学意义（ P <0.05）；实施治疗后组间比较，两组患者两项指标水平差异无统计学意义（P >0.05）；在平均血糖达标时间上，组间比较，观察组患者指标更低，差异具有统计学意义（t =10.0905，P =0.0000）；在血糖达标时胰岛素用量上，组间比较，观察组患者指标更少，差异具有统计学意义（ t =5.8828，P =0.0000）；在低血糖事件发生率上，组间比较，观察组患者指标更低，差异具有统计学意义（χ2=4.9495，P =0.0261）。结论：在临床针对2型糖尿病患者实施治疗的实践过程中，采用地特胰岛素和门冬胰岛素实施治疗的临床效果较好，可靠性更高。
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