抗精神疾病药物对首发分裂症患者泌乳素及性功能影响的对照研究

摘要

目的：探讨抗精神疾病药物对首发分裂症患者泌乳素及性功能影响的对照研究。方法：对72例患者随机分为三组，使用不同药物首发精神疾病患者的泌乳素以及性功能影响进行分析。结果：①氯丙嗪以及利培酮这两组药物对于精神分裂患者泌乳素的波动有显著影响，治疗前后，相关系数有显著差异。②氯丙嗪组以及利培酮组性功能明显下降，达到60%～70%。结论：氯丙嗪及利培酮泌乳素升高明显，性功能下降明显，奎硫平表现良好。%Objective Prolactin and sexual function change with antipsychotic drugs in first-episode schizophrenics were investigated in this study.Methods 72 patients were randomly divided into three groups,and Prolactin and sexual function change with antipsychotic drugs in first episode schizophrenia were analyzed.Results①Chlorpromazine and risperidone have a significant impact in prolactin change,and the correlation coefficient was significantly different before and after treatment.②Sexual function in chlorpromazine and risperidone group was decreased to 60%~70%.Conclusion Prolactin change in chlorpromazine and risperidone increased significantly,and sexual function was significantly decreased as well.Quetiapine have good performance.