七叶皂甙预防肠粘连作用机制的实验研究

摘要

Objective To analyze the clinical effects of aescin in treatment of adhesions.Methods 40 cases of Wistar rats were selected,the appendix serous of rats were scratched and the artery were griped by short clamp,after operation were randomly divided into experimental group and control group,with 20 rats in each group.The experimental group were treated with aescin,the control group were treated with NS,seventh days after operation,the generally adhesions were graded, the OHP(Hyp) levels were analyzed.Results The degree of adhesion of the experimental group were significantly lower than that of the control group,there was statistically significant difference between the two groups(P<0.05);the experiment group levels of OHP and OHP abdominal incisionwere significantly lower than those of the control group,there was statistically significant difference between the two groups(P<0.05).Conclusion Aescin in treatment of adhesions has a define effect,to induce the complication rate of adhesions obviously,is security and stability.%目的：分析研究肠粘连采取七叶皂甙治疗的临床效果。方法：选择Wistar大鼠40只，将其盲肠浆膜刮伤，创面滴入无水乙醇，采用短暂钳将盲肠系膜动脉夹住，手术以后随机分为实验组与对照组，每组20只。实验组实施七叶皂甙给予治疗，对照组实施生理盐水给予治疗，对手术以后第7天实施大体粘连程度分级，并且对OHP（羟脯氨酸）水平进行分析研究。结果：实验组大鼠肠粘连程度明显低于对照组，两组间差异有统计学意义（P＜0.05）；实验组盲肠OHP水平和腹壁切口OHP水平明显低于对照组，两组间差异有统计学意义（P＜0.05）。结论：七叶皂甙对预防肠粘连起到明显的临床效果，使发生肠粘连导致的并发症几率明显减少，具有安全稳定性。