Objective To study the effect of valproic acid on body weight,serum leptin and neuropeptide Y levels in pediatric patients with epilepsy. Method 48 pediatric patients with epilepsy in experiment group who were selected according to the standard of selection were treated with VPA for 6 months. The parameters of body mass index( BMI),serum leptin and neuropeptide Y levels were detected be-fore treatment and 1,3,6 months after treatment. 24 healthy children were divided into the control group. Results At 1,3,6months after treatment in experiment group BMI was(18. 4 ± 1. 05)kg/m2 ,(19. 4 ± 1. 01)kg/m2 and(21. 3 ± 1. 04)kg/m2 respectively,which showed uptrend and were significantly higher than those of the control group(P﹤0. 05). At 1,3,6 months after treatment in experiment group the serum leptin was(4. 59 ± 0. 37)ng/ml,(5. 94 ± 0. 29)ng/ml and(7. 32 ± 0. 21)ng/ml respectively,the serum neuropeptide Y was (132. 21 ± 13. 47)pg/ml,(150. 29 ± 17. 34)pg/ml and(172. 28 ± 20. 76)pg/ml respectively,which both showed uptrend and were sig-nificantly higher than those of their control group(P﹤0. 05). Conclusion The serum leptin and neuropeptide Y levels are increased after valproic acid treatment,which lead the body weight of pediatric patients with epilepsy to increase.%目的：探讨丙戊酸钠（ VPA）对癫痫患儿体重、血清瘦素及神经肽Y（ NPY）的影响。方法：按纳入标准收集首次诊断癫痫后VPA单药治疗的患儿48例作为试验组，于治疗前、治疗后1、3、6个月测定患儿体质量指数（ BMI），检测血清瘦素、NPY水平。另选择24例健康儿童作为对照组。结果：试验组治疗后1个月、3个月、6个月 BMI 指数分别为（18.4±1.05）kg/m2、（19.4±1.01）kg/m2和（21.3±1.04）kg/m2，呈上升趋势，明显高于对照组，差异具有统计学意义（P﹤0.05）。试验组治疗后1个、3个、6个月血清瘦素分别为（4.59±0.37）ng/ml、（5.94±0.29）ng/ml和（7.32±0.21）ng/ml，NPY分别为（132.21±13.47） pg/ml、（150.29±17.34）pg/ml和（172.28±20.76）pg/ml，两者均呈现出上升趋势，且两者均明显高于对照组，差异具有统计学意义（P﹤0.05）。结论：VPA能够使癫痫患儿的瘦素、NPY水平升高，导致患儿体重增加。
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